RBX1-23

• Submission order: 23
• Score rank: 23
• Format: Mini-protein
• Primary state: 2LGV display state
• Design method: Proteina seed plus ProteinMPNN redesign
• Description: This Proteina-derived reserve was kept because it expands the 2LGV lane with compact alternative scaffolds that are sequence-distinct from the earlier long display-state constructs, even though interface evidence is still catching up. The working model targets the 2LGV display-state RBX1 surface used for orthogonal geometry exploration in the 2LGV display state, and current structural support remains centered on that state. The key numerical signals are a modeled contact patch built around 1 residue on the binder side, a patch that currently touches 1 residue on RBX1, solid interface confidence at 0.612, acceptable developability at 0.860, and a composite ranking score of 3.3780. Novelty review does not show a disqualifying signal in the present screen set; no strong competing interaction is flagged in the off-target screen; the main caution is that current structural evidence is still centered on one RBX1 conformation rather than a recovered cross-state contact pattern; the full project rationale and design workflow are documented at https://github.com/tuna010101/RBX1-Binder-Design-Portfolio