RBX1-14

• Submission order: 14
• Score rank: 14
• Format: Mini-protein
• Primary state: 4F52 main-face state
• Design method: BindCraft backbone plus ProteinMPNN redesign
• Description: This entry remains in the set because it provides another structurally distinct backup inside its route, which is still useful while none of these designs has experimental binding data. The working model targets the main RBX1 surface represented by the 4F52 Glomulin-blocked reference in the 4F52 main-face state, and current structural support remains centered on that state. The key numerical signals are a modeled contact patch built around 1 residue on the binder side, a patch that currently touches 1 residue on RBX1, localized RBX1 surface coverage of 0.056, high interface confidence at 0.889, strong developability at 0.948, and a composite ranking score of 5.5406. Novelty support is acceptable: the UniRef50 30-aa sliding-window screen is clear; no strong competing interaction is flagged in the off-target screen; the main caution is that current structural evidence is still centered on one RBX1 conformation rather than a recovered cross-state contact pattern; the full project rationale and design workflow are documented at https://github.com/tuna010101/RBX1-Binder-Design-Portfolio