Miniprotein
RBX1
Yes
rbx1_gen_0017|helix_v2_N4K,R7I,T11I,D13A|iPTM=0.888|pLDDT=0.810|composite=0.7186
EREKDRIADEIRA
This protein was designed using BCSAE-Steered ESM2 + Topological Pre-Filtering + Boltz-2
Base model: facebook/esm2_t33_650M_UR50D (650M params, MPS-accelerated) SAE: InterPLM esm2-650m layer 18 (HuggingFace: Elana/InterPLM-esm2-650m) Steering feature: f5922 (helix), clamp=10.0 Topo filter: PH-entropy <= 1.1841 (linear), computed via ripser on Vietoris-Rips filtration Variants per parent: 5 (4 mutations each, temperature=1.0) Boltz-2 for structure prediction Target: RBX-1 RING domain residues 40-108, PDB 1LDK