Adaptyv EGFR Binder Design Competition 1
Design novel protein binders targeting EGFR, a cell-surface receptor that promotes uncontrolled cell growth in many cancers.
Overview
- Stage 1Computational Design
Submit your computational protein designs. 200 designs will be selected for experimental validation, 100 by the best pAE_interaction,100 based on the rule of cool
Submissions OpenJul 18, 2024/
Submissions CloseAug 18, 2024 - Stage 2Experimental Validation
Selected designs undergo experimental validation in the Adaptyv Lab. Proteins with the highest binding affinity win the competition.
Validation startsAug 19, 2024/
Results releasedOct 18, 2024
- Stage 1Computational Design
Submit your computational protein designs. 200 designs will be selected for experimental validation, 100 by the best pAE_interaction,100 based on the rule of cool
Submissions OpenJul 18, 2024/
Submissions CloseAug 18, 2024 - Stage 2Experimental Validation
Selected designs undergo experimental validation in the Adaptyv Lab. Proteins with the highest binding affinity win the competition.
Validation startsAug 19, 2024/
Results releasedOct 18, 2024
About the Target
EGFR
PDB: 1IVO
Sequence
Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein that plays a critical role in cell growth, differentiation, and survival. It is frequently overexpressed or mutated in various cancers, including non-small cell lung cancer, colorectal cancer, and head and neck cancer. This makes EGFR a crucial target for cancer therapies such as Cetuximab, an antibody with more than 1B USD in annual revenue.
In this competition, you can test your skills as a protein designer by designing a binding protein to the extracellular domain of EGFR_HUMAN. You sould optimize both affinity and specificity.