Submission 1

schmoo/Submission 1

Description

We reviewed the previous literature and analyzed the natural binding pocket and the binding sites of neutralizing antibodies. We then selected the neutralizing antibody binding interface reported in earlier studies as the hotspot for binder design and carried out subsequent design and screening.

Proteins (10)

TableGrid

Sschmoo

id: shy-dove-wave

Binder

Miniprotein

PXDesign Server

Target

Nipah Virus Glycoprotein G

None

87.71

True

9.3 kDa

id: radiant-zebra-frost

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

None

83.11

True

15.2 kDa

133

id: frozen-ibis-ash

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

None

88.25

True

15.6 kDa

135

id: rapid-goat-pine

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

None

86.55

True

17.9 kDa

157

id: scarlet-bison-pearl

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

None

87.74

True

14.3 kDa

125

id: rapid-lynx-rose

Binder

Miniprotein

PXDesign Server

Target

Nipah Virus Glycoprotein G

0.76

87.66

9.2 kDa

id: jade-seal-ember

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

0.75

87.11

13.2 kDa

116

id: quiet-fox-ivy

Binder

Miniprotein

PXDesign Server

Target

Nipah Virus Glycoprotein G

0.00

89.72

9.5 kDa

id: silent-crane-ember

Binder

Other

PXDesign Server

Target

Nipah Virus Glycoprotein G

0.36

89.05

17.0 kDa

147

id: scarlet-seal-marble

Binder

Miniprotein

PXDesign Server

Target

Nipah Virus Glycoprotein G

0.09

84.98

10.3 kDa