We computationally designed 2,000 candidate binders and ranked them using iPTM and PAE scores, selecting the top 10 designs after a ~23-hour GPU run. The final set consists of 8 antibody-based binders and 2 α-helical binders. Our primary hypothesis is that at least one of the antibody binders will show measurable binding, but we also included the α-helical designs because they achieved the highest structural confidence scores and may provide a compact, highly stable alternative scaffold.
id: ivory-lion-leaf

Nipah Virus Glycoprotein G
None
87.48
True
13.1 kDa
121
id: green-cobra-bronze

Nipah Virus Glycoprotein G
None
87.43
True
13.9 kDa
128
id: pale-mole-snow

Nipah Virus Glycoprotein G
None
90.72
True
10.7 kDa
110
id: quick-ox-vine

Nipah Virus Glycoprotein G
None
91.79
True
15.3 kDa
149
id: crimson-dove-frost

Nipah Virus Glycoprotein G
None
81.23
True
15.0 kDa
149
id: pale-seal-lotus

Nipah Virus Glycoprotein G
None
88.86
True
12.1 kDa
113
id: calm-orca-lava

Nipah Virus Glycoprotein G
None
84.88
True
13.3 kDa
125
id: frozen-falcon-reed

Nipah Virus Glycoprotein G
None
84.70
True
13.3 kDa
122
id: violet-ibis-vine

Nipah Virus Glycoprotein G
None
87.50
True
12.0 kDa
113
id: golden-swan-cloud

Nipah Virus Glycoprotein G
0.04
86.06
--
16.4 kDa
149