Strawbinder is the simplest sequence-based baseline approach. Starting from an extracellular domain of the ephrin-B2 receptor, it performs random search by mutating 2 AA's ata time with the maximum edit distance capped at 32. At each round of random mutation, ProGen2 (yes, it is indeed a baseline) to score each mutated sequence against the Nipah virus. After up to 100 rounds, we select top-10 resulting sequences based again on ProGen2.

The code (including GUI) can be found as opensource at https://github.com/kyunghyuncho/strawbinder/.