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Nipah Binder Competition

Nipah Virus Glycoprotein G

1000 proteins validated

Design a protein capable of neutralizing the Nipah virus, a pathogen with up to 75% mortality rate and high pandemic potential, currently lacking effective treatments.

Adaptyv Bio

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Featured Proteins

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MIOTMassachusetts Institute of Technology

id: noble-bat-topaz

Binder

Nanobody

BoltzGen

Target

IL-7Ra

Binding

Strong

1.4e-9 M

True

12.5 kDa

119

id: lunar-zebra-topaz

Binder

scFv

Target

EGFR

Binding

Strong

1.9e-9 M

True

25.9 kDa

241

id: brisk-boar-cloud

Binder

Other

EvoDiff

Target

MDM2

Binding

Strong

1.7e-7 M

True

12.1 kDa

102

id: golden-cobra-iron

Binder

Other

BindCraft

Target

IFNAR2

Binding

Medium

5.7e-8 M

Expressed

True

Mol. Weight

11.1 kDa

AA Length

Featured Collections

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Nipah Binder Competition: Main Submissions

Adaptyv Bio • 10 days ago

Binding data

3749 proteins

1 targets

All proteins from designated competition submissions

+3744

BoltzGen Release

Massachusetts Institute of Technology • about 2 months ago

Binding data

422 proteins

14 targets

To validate BoltzGen in its initial preprint release, 422 designed proteins were experimentally tested against 14 distinct targets.

+417

Cradle EGFR Competition Follow Up

Cradle • about 2 months ago

Binding data

12 proteins

1 targets

12 EGFR binders designed by Cradle for the Adaptyv 2024 protein design competition, generated through Cradle's zero-shot diversification pipeline.

Popular Design Methods

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BoltzGen

All-atom diffusion-based generative model developed for de novo design of protein and peptide binders across a wide array of target types

1241 proteins generated

422 proteins tested

BindCraft

Protein binder design pipeline that can be used to design miniprotein and peptide binders

598 proteins generated

141 proteins tested

RFdiffusion

A flexible de novo binder design workflow using RFdiffusion for backbone generation

272 proteins generated

90 proteins tested

Popular Targets

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EGFR

protein

826

Proteins validated

134

Binders

Epidermal Growth Factor Receptor (EGFR) regulates cell growth and differentiation. Alterations in its activity are linked with cancer progression and treatment resistance.

IL-7Ra

other

Proteins validated

Binders

IL-7Ra is a receptor critical for the development and homeostasis of immune cells. Altered levels of IL-7Ra are associated with immune deficiencies and autoimmune disorders.

PD-L1

protein

Proteins validated

Binders

PD-L1 (Programmed Death-Ligand 1) modulates immune responses by interacting with PD-1 on T cells. Altered PD-L1 levels are associated with immune evasion in cancers.

Insulin Receptor

protein

Proteins validated

Binders

The insulin receptor controls how cells take up glucose. Changes in its signaling contribute to poor blood-sugar control and diabetes.